Anjul Agarwal
anjul_g@rediffmail.com
International Journal of ChemTech Research
IJCTR
0974-4290
2455-9555
10.20902/CT
http://www.sphinxsai.com/chemtech.php
2019
12
03
The Effect of Rhizome Extract of Curcuma (Curcuma xanthorriza Roxb) for Cell Injury in Histopathology of Liver Tissue of Male White Mice (Mus musculus L.) Strain BALB/C Infected by Plasmodium berghei Anka
Bagah Restu
Pambudi
1
Prawesty Diah
Utami
2
Retno
Budiarti
3
Faculty of Medicine, Universitas Hang Tuah, Surabaya, Indonesia
Department of Parasitology, Faculty of Medicine, Universitas Hang Tuah, Surabaya,
Indonesia
Department of Microbiology, Faculty of Medicine, Universitas Hang Tuah, Surabaya,
Indonesia
2019
01
07
120301
10.20902/IJCTR.2019.120301
http://dx.doi.org/10.20902/IJCTR.2019.120301
Background: Malaria is a dangerous disease that can cause death. Curcuma
xanthorriza Roxb. contains curcumin as an antiinflammatory and natural antioxidant which has
a hepatoprotector function.
Objective: To know the effect of rhizome extract of curcuma (Curcuma xanthorriza Roxb) on
cell injury in histopathology of male mice’s (Mus musculus L.) liver tissue which were infected
by Plasmodium berghei ANKA.
Methods: The methods of the study are laboratory experimental study with the design areposttest
only randomized group. Using 25 mice divided randomly into 5 groups that are: normal
mice group (K1), aquadest group (K2), ginger group 150mg/kgBW (K3), ginger group
100mg/kgBW (K4), ginger group 50mg/kgBW (K5). Onthe fifth day of experiment, liver
histopathology observation was performed.
Results:Descriptively the results show a decrease in cell injury in cell histopathology of the
liver tissue of mice. The higher the dose given the smaller the results of scoring cell injury.
However, the results of the Mann-Whitney U statistical test were of significance between the
groups given curcuma xanthorriza Roxb extract. 150 mg/kg body weight, 100 mg/kg body
weight, 50 mg/kg body weight more than 0.05 (Sig <0.05).
Conclusion: The administration of 150mg / BB extract of curcuma rhizome (Curcuma
xanthorriza Roxb.) Had a descriptive effect but was not analytically significant on cell injury in
histopathology of liver tissue of male mice (Plasmodium berghei ANKA).
http://sphinxsai.com/2019/ch_vol12_no3/1/(01-07)V12N3CT.pdf
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ginger rhizome (Curcuma xanthorriza Roxb.)
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