Anjul Agarwal
anjul_g@rediffmail.com
International Journal of ChemTech Research
IJCTR
0974-4290
2455-9555
10.20902/CT
http://www.sphinxsai.com/chemtech.php
2018
11
11
Polymeric Micelles of Capecitabine: Design, Characterization & Cytotoxic Study
HD
Nayanika
1
S
Subramanian
1
Department of Pharmaceutics, PSG-College of Pharmacy, Coimbatore,
Tamilnadu, India
2018
115
122
111111
10.20902/IJCTR.2018.111111
http://dx.doi.org/10.20902/IJCTR.2018.111111
The present study was aimed to prepare polymeric micelles of capecitabine: design,
characterization & cytotoxic study. Capecitabine is a prodrug used in the treatment of
metastatic colorectal cancer and breast cancer. Polymeric micelles formulations are being
formulated to achieve smaller particle size, good stability, increase the solubility, and prolong
release of the drug. The micelles have been prepared by using organic solvent/water emulsion
technique. Then the prepared formulation has been undergone for drug content, entrapment
efficiency, particles size, zeta potential. From this best formulation is converted into tablets by
using the excipients. Preformulation study was carried out by using with and without
excipients. Then tablets were made using direct compression method by using 9mm concave
punches in rotary tablet press. Then the tablet is dip coated using ethyl cellulose of different
concentrations. The formulations were evaluated for thickness, hardness, disintegration,
dissolution. The tablets shows release formulation upto 12 h.Cytotoxic study has been done in
human colon cancer (HT-29) cells by using MTT assay
http://sphinxsai.com/2018/ch_vol11_no11/1/(115-122)V11N11CT.pdf
Capecitabine
polymeric micelles
entrapment efficiency
dip coating
ethyl cellulose
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