Anjul Agarwal
anjul_g@rediffmail.com
International Journal of ChemTech Research
IJCTR
0974-4290
2455-9555
10.20902/CT
http://www.sphinxsai.com/chemtech.php
2018
11
10
Design, Formulation and Evaluation of Topical Nimesulide Emulgel
Kamlesh
Wadher
1
Diksha
Patel
1
Sagar
Trivedi
1
Milind
Umekar
1
Department of Pharmaceutical Technology, Smt. KishoritaiBhoyar College of
Pharmacy, Kamptee, Nagpur, India-441002
2018
52
59
111008
10.20902/IJCTR.2018.111008
http://dx.doi.org/10.20902/IJCTR.2018.111008
Emulgel is one of the recent technologies in Novel DDS used for dual control
release of emulsion and gel for topical use. In the present Investigation, topical gel and
emulgels of Nimesulide were formulated using 23 Factorial Design and Carboplol 934 as a
polymer.The oral use of Nimesulide is associated with side effects like gastrointestinal
disturbances, epigastric pain, nausea, heartburn, vomiting and diarrhea. Topical application of
the drug prevents these side effects and offers potential advantage of delivering the drug at the
site of action. The rational of the present study was to increase the penetration of drug into
the skin.The Formulations were subjected to various physicochemical studies such as
spreading coefficnt, Vioscosity and in vitro release studies. In vitro release of the tests
formulations was performed to determine drug release from Gel and emulgel. From the in
vitro studies, formulation F4 showed maximum release of 59.58% in 240 min and 45.02%
from the Gel. In vitro release studies of the prepared formulation were performed using
dialysis membrane and results indicated that Emulgel showed better release than Gel system
http://sphinxsai.com/2018/ch_vol11_no10/1/(52-59)V11N10CT.pdf
Emulgel
Topical Drug delivery
Nimesulide
Drug release kinetics
J Pain Research
Lionberger DR, Brennan MJ
3
223
2010
International
Journal of Drug Delivery
Kumar L, Verma R
2
58
2010
Eccleston GM, Swarbrick J, Boylan JC, eds. Encyclopedia of Pharmaceutical Technology. Vol.5,
Marcel Dekker Inc,1992:137- 188
AAPS Journal
M. I. Mohamed
6
3
26
2004
Journal of Applied Physics
Ogura M ,Sato S, Kurok iM, et. al
41
814
2002
Int. J. Pharma
Hardenia A, Jayronia S , Jain S et. al
5
5
1653
2014
Asian Journal of Pharmacy And Life
Sciences
Panwar A S,Upadhyay N,Bairagi N ,et. al
1
3
333
2011
Indian
J. Pharm. Sci.
Jawahar N, Jayaprakash S, Maria Gerald Rajan NS, Nagarajan M, Dhachina Moorthi D, Jubie S,Manivannan R
67
5
558
2005
Indian
J. Pharma Sci.
Sagar BSH, Pimpale R
68
5
622
2006
Pelagia Research Library
Snehal P, Kiran A, Manish A, et.al
4
5
31
2013
Int.J..Pharma
Tech Res.
Khunt D, Mishra A, Shah D
4
3
1332
2012
J. Control. Rel.
Ajazuddin S, Alexander A, Gupta S, et.al
171
122
2013
Asian Journal of Pharmacy And Life
Sciences
Panwar S,Upadhyay N, Bairagi N ,et. al
1
3
333
2011
Bulletin of Faculty of Pharmacy, Cairo University
Abd El-Bary, S. Shalaby, and S. Abd El-Aal
39
89
2001
European
Journal of Pharmaceutical Sciences
Barry B
14
101
2001
The International Journal of
Aromatherapy
Buck P
1
70
2004
Critical Reviews™ in Therapeutic Drug Carrier
Purdon C , Azzi G, Zhang J, Smith E
21
97
2004
Pharmazie
Gungor S, Bergisadi N
58
155
2003
Gupta S. and Pandit KR. Concepts of Pharmaceutical Dosage Form, 9th Edn., B.S. Shah Publication,
Delhi, 1997, 155-156
Int. J. PharmTech Res.
Wadher KJ, Nagarkar AT, Umekar MJ etal
5
2
773
2013
Saudi Pharmaceutical Journal
Khullar R,Kumar D,Seth N, et.al
20
63
2012
Int.J.University Pharmacy And Bio
Mathew F, Mathew N, Eldhose M et. al
5
4
101
2016
M. E. Aulton (ed.), In Transdermal drug delivery, Pharmaceutics: The science of dosage form design.
(2nded.).Churchill Livingstone, New York; 2002.: 499-533
Int.J.Pharma Research And Bio- Science
Patel J ,Trivedi J , Chudhary S et. al
3
2
625
2014
Am. J. Pharmtech Res.
Panwar S ,Mulkhopadhyaya S, Kothiyal P
5
6
480
2015
R H Guy, JHadgraft, Percutaneous penetration enhancement: physicochemical considerations and
implications for prodrug design. In Prodrugs: Topical and Ocular Drug Delivery, K. B. Sloan (ed.),
Marcel Dekker Inc., New York, USA, 1999: 1 –27
Roberts M S, Cross S E, Pellett M A, Walters K.A (ed.), Marcel Dekker Inc., Skin transport. In
Dermatological and Transdermal Formulations, New York, USA, 2002: 89 - 195
Robinso J R, Lee VHL, “Controlled drug delivery”, Fundamental applications, 2nded. Marcel Dekker:
New York; 1987:29-53
European Journal of Pharmaceutical Sciences
Schnetz E, Fartasch M
12
165
2001
Int. J.
Pharma And Bio Sciences
Singla V, Saini S, Joshi E,et.,al
3
1
485
2012