Anjul Agarwal
anjul_g@rediffmail.com
International Journal of PharmTech Research
IJPTR
0974-4304
2455-9563
10.20902/2017
http://www.sphinxsai.com/pharmtech.php
2019
12
01
Activity of Ethanol extract of Passiflora foetida Linn leaves on Hypersensitivity Response of Immune cells in vivo
Andi
Emelda
1
Arman
2
Aulia
Wati
3
Firayanti
Hamka
4
Faculty of Pharmacy, Universitas Muslim Indonesia,
Jl. Urip SumoharjoKm.5 Makassar 90231, South Sulawesi Indonesia
Faculty of Public Health, Universitas Muslim Indonesia,
Jl. Urip SumoharjoKm.5 Makassar 90231, South Sulawesi Indonesia
Faculty of Pharmacy, Universitas Muslim Indonesia,
Jl. Urip SumoharjoKm.5 Makassar 90231, South Sulawesi Indonesia
Faculty of Pharmacy, Universitas Muslim Indonesia,
Jl. Urip SumoharjoKm.5 Makassar 90231, South Sulawesi Indonesia
2019
24
27
120104
10.20902/IJPTR.2019.120104
http://dx.doi.org/10.20902/IJPTR.2019.120104
Passiflora foetida L leaves contain flavanoid compounds. Some studies on
flavonoids show that flavonoids can modulate the immune system. The purpose of this study
was to determine the difference of ethanol extract dose of passiflora foetida L.leaves to
immonomodulator. Tests on Delayed Type Hypersensitivity using dose of 0.4 g/kgbw, 0.8
g/kgbw, and 1.2 g/kgbw. The extract was given for 7 days. The hypersensitivity response test
was performed using 25 mice (Balb/c) divided into 5 groups: control, negative control, extract
groups dose of 0.4 g/kgbw, 0.8 g/kgbw, and 1.2g/kgbw. The groups, except control group,
were given antigen (SRBC) on the 3rd day intraperitoneally and on the 7th day were
administered intraplantarly. The thickness of the soles of the feet was measured using a
plethysmometer before and after injecting the antigen at T4, T24 and T48. The extracts dose of
0.4, 0.8, and 1.2 g/kgbw showed that swelling of the feet of mice decrease compared to control
group.The results showed that the dose of 0.4 g/kgbw, 0.8 g/kgbw, and 1.2 g/kgbw showed no
significant difference (p> 0.05)
http://sphinxsai.com/2019/ph_vol12_no1/1/(24-27)V12N1PT.pdf
Passiflora foetida (L.) leaves
Delayed Type Hypersensitivity
imunomodulator
J. Ethnopharmacol
Dhawan K., Dhawan S., Sharma A.
94
1
2011
10.1016/j.jep.2004.02.023
https://doi.org/10.1016/j.jep.2004.02.023
Phytochemistry
Echeverri F., Arango V., Quinones W., TorresF., Escobar G., Rosero Y., Archbold R.
56
881
2001
10.1016/S0031-9422(00)00478-7
https://doi.org/10.1016/S0031-9422(00)00478-7
Emelda A., Immunomodulatory Activity Of Ethanol Extract Of Passiflora foetida Linn on Secretion of
Primary and Secondary Antibodies In pre-Clinical. Proceeding ofthe3rd International Seminar of Natural
Product,2017, pp. 84-86
Sains Malaysiana
NizamW.A., Ho Y.M.,Rosli W.W.I.
45
2
195
2016
Mar. Drugs
Joao C.F., Humberto S., Vanessa D.S., Alice S.S., Manuela E.P., Francisco X.M., JoaoE.C
8
1763
2010
10.3390/md8061763
https://doi.org/10.3390/md8061763
International Journal of Pharmaceutical Research & Allied Sciences
Mitul P.M., Shivalinge G.K.P.
1
2
1
2012
Abbas A.K., Lichtman A.H., Pillai S., Cellular and Molecular Immunology. 7th Edition. Philadelphia:
Saunders Elsevier, 2012
International Food Research Journal
Emelda A., Wahid S., Massi N., Wahyudin E.
24
3
1321
2017
International Journal of Pharmacy & Technology
Emelda A., Arman, Yuliana D., Amin A.
7
3
9562
2015
Journal of Chemical and
Pharmaceutical Research
Arman, EmeldaA., Yuliana D., AuliaW.,Ervita
7
10
470
2015
Johnson A.G., Ziegler R.J., Hawley L., Microbiology and Immunology, 5th Edition, Wolters Kluwer
Health: Lippincott Williams & Wilkins, 2010
Baratawidjaja G.K., Rengganis I., Basic Immunology. Jakarta: Publisher FKUI, 2012