Anjul Agarwal
anjul_g@rediffmail.com
International Journal of PharmTech Research
IJPTR
0974-4304
2455-9563
10.20902/2017
http://www.sphinxsai.com/pharmtech.php
2018
11
4
The Effect of Turmeric Rhizome (Curcuma Longa Linn)On Decreasing Non-Alcoholic Steatohepatitis in Deep Frying Oil Induced Male Wistar Rats
Karmila
Kaban
1
Sunarti
1
Faculty of Nursing and Midwifery, University of Prima Indonesia
2018
361
367
11407
10.20902/IJPTR.2018.11407
http://dx.doi.org/10.20902/IJPTR.2018.11407
Deep Frying oil/ DFO is cooking oil from high and repetitive heating temperatures.
The use of DFO can increase steatosis hepatocyte with inflammation and hepatocellular injury
(balloning hepatocytes) which is a typical sign ofNon-alcoholic steatohepatitis/ NASH. This
disease must be treated as quickly as it can cause complications of liver cancer and liver
cirrhosis. Turmeric rhizomes containing curcumin was active anti-oxidants which can inhibit
fat accumulation intra-hepatic. The present study was conducted to evaluate the effect of
turmeric rhizome to reduce fat degeneration in male Wistar rats in the NASH model. This study
was experimental with a randomized post-test only control group design. The number of 24
samples consisted of four treatment groups. Group I (control): normal diet + DFO (10 μl/g
/day), Group II, III and IV: normal diet + DFO + turmeric extract doses (100, 200, and 400 mg
/kg BW/day, orally for 30 day at 6 times frying. The results of the Kruskal-Wallis test showed
significant differences between the four treatment groups in steatosis (P <0.05) and there were
no significant differences in hepatocyte ballooning and lobular inflammation. The results of
Mann-Whitney test showed significant differences in hepatocyte stestosis between the control
group (P1) and the treatment group (P3) with a dose of 200 mg / kg BW.It showed that the dose
was effective inhibit of NASH
http://www.sphinxsai.com/2018/ph_vol11_no4/1/(361-367)V11N04PT.pdf
Turmeric
NASH
DFO
fat degeneration
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