Anjul Agarwal
anjul_g@rediffmail.com
International Journal of ChemTech Research
IJCTR
0974-4290
2455-9555
10.20902/CT
http://www.sphinxsai.com/chemtech.php
2018
11
10
Association of the Monocyte to HDL Cholesterol Ratio With Coronary Artery Disease Severity in Patients With Acute Coronary Syndrome
Dicky
Yulianda
1
Abdullah A.
Siregar
1
Zulfikr
Mukhtar
1
Refli
Hasan
1
Harris
Hasan
1
Cut A.
Andra
1
Department of Cardiology and Vascular Medicine, University of Sumatera Utara,
Adam Malik Hospital, Medan, Indonesia
2018
95
102
111013
10.20902/IJCTR.2018.111013
http://dx.doi.org/10.20902/IJCTR.2018.111013
Background : Monocytes and tissue macrophages play a pivotal role in
atherosclerotic plaque formation. HDL cholesterol has an anti-inflammatory effects and can
inhibite monocyte activation. The ratio of monocyte count/HDL cholesterol (MHR) is a
parameter that has recently been studied and can widely used and also has a value of
prognosis. The RMH predictive value for assessing the severity of coronary artery has not
been widely studied. This study aims to evaluate whether the MHR value can be a predictor of
the severity of coronary artery lesions in patients with acute coronary syndromes (ACS).
Methods : This retrospective cohort study of 97 patients with ACS undergoing coronary
angiography and treatment at Adam Malik Hospital from January 2015 – April 2018. Patients
were divided into two groups based on Gensini score, severe coronary lesions (Gensini ≥ 30)
and mild coronary lesions (Gensini < 30). Bivariate, multivariate and correlation analysis were
performed to find the relationship between MHR and Gensini score as well as finding
meaningful RMH cutoff points. The p value < 0.05 was considered statistically significant.
Results : Of the 97 patients with ACS, 48 subjects (49.5%) were scored with a high Gensini
score and 49 subjects (50.5%) with low Gensini score. The ROC curve analysis obtained
MHR cutoff value in predicting the severity of coronary artery lesion was 0.021 (AUC 0.725,
95% CI 0.623-0.827, p<0.046)with a sensitivity of 70.3% and specificity of 45%. This study
found a significant relationship but with a weak correlation between MHR value and Gensini
score (p=0.006)(r=0.252). Logistic regression analysis showed MHR value ≥ 0.021 (OR 2.68,
95%CI 1.069-6.716, p=0.035) along with moderate to high TIMI score (OR 4.682, 95%CI
1.445-15.168, p<0.01) became an independent factor for predicting the severity of coronary
artery lesions.
Conclusion : There is a positive but weak correlation between the MHR value and the
severity of coronary artery lesions in ACS patients. MHR value ≥ 0.021 is an independent
factor in predicting the severity of coronary artery lesions in patients with ACS
http://sphinxsai.com/2018/ch_vol11_no10/1/(95-102)V11N10CT.pdf
MHR
Gensini
ACS
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